Why take CBD, what are its indications?

Pourquoi prendre du CBD, quelles sont ses indications?

Analysis of the literature on the use of CBD reveals the following reasons for consumption (1, 2) and indications:

Pain (3, 5, 6) and inflammation (4,11), insomnia (12), anxiety (12) , depression (13) , nausea (7, 14), the fight against addictions (3 ,10), muscle recovery , tremors (16), bulimia and obesity (15) .

This investigation highlights that CBD is also consumed to relax without having to experience the psychoactive effects or anxiety associated with THC.

Concerning the frequency of consumption, 80% say they consume CBD at least once a week and 41% daily.

55% buy CBD products in stores, 31% use delivery services and 17% buy online.

A reduction in pain (3, 5, 6) has been observed, particularly in people suffering from cancer or arthritis, without CBD altering the effectiveness of treatments such as chemotherapy.

Concerning the properties of CBD to reduce nausea and vomiting, promising results concerning patients undergoing chemotherapy have still been observed during the administration of the drug Sativex®, an oral spray containing CBD (3, 5, 6, 7).

In 2018, the CBD drug Epidiolex® was approved by the FDA (Food and Drug Administration) in the United States to treat two severe forms of pediatric epilepsy, Dravet syndrome and Lennox syndrome. Gastaut (8, 9).

CBD may have therapeutic value in the treatment of substance abuse (3, 10). According to several studies, it reduces the effects induced by morphine at the level of the reward circuit, as well as the heroin-seeking behavior of patients.

This was notably observed in an animal study in which heroin was administered to rats, followed by CBD at a rate of 5 mg per kilo.

Regarding eating disorders and obesity, some studies show positive effects of CBD.

According to them, CBD could have therapeutic potential to reduce binge eating and the development of obesity (15).

One explanation put forward would be that CBD, by reducing anxiety, would reduce the risk of uncontrolled food intake with anxiolytic purposes generated by stress.

Important to note:

To date, health authorities do not consider CBD cannabidiol as a medicine.


1 Hello MD, Brightfield Group, Summary Report, July 2017

Understanding Cannabidiol | CBD Summary Report

2 Whiting, PF, Wolff, RF, Deshpande, S., Di Nisio, M., Duffy, S., Hernandez, AV, Keurentjes, C., Lang, S., Misso, K., Ryder, S., Schmidlkofer , S., Westwood, M. & Kleijnen, J. (2015). Cannabinoids for medical Use: A systematic review and meta-analysis . JAMA, 313 (24), 2456-2473.

3 Volkow, N.D. (2015, June). The biology and potential therapeutic effect of cannabidiol . Senate Caucus on International Narcotics Control.

4 Burstein, S. (2015), Cannabidiol (CBD) and its analogs: a review of their effects on inflammation. Bioorganic & Medicinal Chemistry, 23 , 137-1385.

5 Morabito, D., Soyster, P., Ramey-Wright, S., Belendiuk, KA & Bonn-Miller, MO (2016). A Review of Recent Advances in the Therapeutic Uses of Secondary Cannabinoids. Current Addiction Reports, 3 , 230-238.

6 Grotenhermen, F. & Müller-Vahl, K. (2017). Medicinal Uses of marijuana and Cannabinoids. Critical Reviews in Plant Sciences, 35 (5-6), 378-405.

7 National Academies of Sciences, Engineering, and Medicine (2017). The health effects of cannabis and cannabinoids: The current state of evidence and recommendations for research . Washington, DC: The National Academies Press. doi:10.17226/24625.

8 Devinsky O, Cilio MR, Cross H, et al.

Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders.


9 Campos AC, Fogaça MV, Sonego AB, Guimarães FS. Cannabidiol, neuroprotection and neuropsychiatric disorders.

Pharmacol Res 2016;112:119-127.

10 Iffland, K. & grotenhermen, F. (20179. An update on safety and side effects of cannabidiol: a review of clinical data and relevant animal studies. Cannabis and Cannabinoid Research , 2(1), 139-154.

11 Dos-Santos-Pereira M, Guimarães FS, Del-Bel E, Raisman-Vozari R, Michel PP. Glia. 2019 Oct 24. Cannabidiol prevents LPS-induced microglial inflammation by inhibiting ROS/NF-κB-dependent signaling and glucose consumption.

12 Scott Shannon , MD,1 Nicole Lewis , ND,2 Heather Lee , PA-C,3 and Shannon Hughes , PhD. Perm J. 2019; 23:18-041. Published online 2019 Jan 7. doi: 10.7812/TPP/18-041

Cannabidiol in Anxiety and Sleep: A Large Case Series

13 María S. García-Gutiérrez, Francisco Navarrete, Ani Gasparyan, Amaya Austrich-Olivares, Francisco Sala, Jorge Manzanares. Biomolecules. 2020 Nov; 10(11): 1575. Published online 2020 Nov 19. doi:10.3390/biom10111575. Cannabidiol: A Potential New Alternative for the Treatment of Anxiety, Depression , and Psychotic Disorders

14 Erin M. Rock , Cheryl L. Limebeer , Roger G. Pertwee , Raphael Mechoulam , and Linda A. Parker. Cannabis Cannabinoid Res. August 2021; 6(4): 266–274. Published online 2021 Aug 5. doi: 10.1089/can.2021.0041. Therapeutic Potential of Cannabidiol, Cannabidiolic Acid, and Cannabidiolic Acid Methyl Ester as Treatments for Nausea and Vomiting

15 Guo-Hua Bi, Ewa Galaj, Yi He , and Zheng-Xiong Xi

Addict Biol. Author manuscript; available in PMC 2021 Jul 1.

Published in final edited form as: Addict Biol. 2020 Jul; 25(4): e12783. Published online 2019 Jun 19. doi: 10.1111/adb.12783. PMCID: PMC6920611. NIHMSID: NIHMS1028474. PMID: 31215752. Cannabidiol inhibits sucrose self-administration by CB1 and CB2 receptor mechanisms in rodents.

16 Felipe Patricio , Alan Axel Morales-Andrade , Aleidy Patricio-Martínez , and Ilhuicamina Daniel Limón. Front Pharmacol. 2020; 11:595635.

Published online 2020 Dec 15. doi: 10.3389/fphar.2020.595635.

Cannabidiol as a Therapeutic Target: Evidence of its Neuroprotective and Neuromodulatory Function in Parkinson's Disease

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